Fundación Mario Santo Domingo is a nonprofit organization dedicated to promoting the common good and social development of the Colombian people, especially for the poorest sections of the population.

Mario Santo Domingo, a successful entrepreneur in the city of Barranquilla, established his foundation in 1960. Originally named La Fundación Barranquilla, the foundation supported educational institutions and other organizations dedicated to philanthropic work. A change came in 1989, when the board of directors voted to rename the organization and refocus efforts. Currently, the foundation's goals include improving living conditions for destitute families, retraining workers, building homes for the poor and supporting microenterprise development with loans and business training.